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2 edition of Drug delivery coatings for nitinol stents to prevent intimal hyperplasia found in the catalog.

Drug delivery coatings for nitinol stents to prevent intimal hyperplasia

Kathryn Davenport

Drug delivery coatings for nitinol stents to prevent intimal hyperplasia

by Kathryn Davenport

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  • 13 Currently reading

Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (Ph.D.) - University of Birmingham, School of Dentistry, Biomaterials Unit, 2003.

Statementby Kathryn Davenport.
The Physical Object
Pagination299 p. :
Number of Pages299
ID Numbers
Open LibraryOL20417127M

  To overcome the intimal hyperplasia resulting from PCI coupled with the use of bare metal stents, drug-eluting stents (DES) were employed to locally deliver antirestenotic therapeutics. Since FDA approval of the first DES, it is estimated that approximately million DESs have been implanted, accounting for more than 75% of all stents :// Stenting is an alternative to endarterectomy for the treatment of carotid artery stenosis. However, stenting is associated with a higher risk of procedural stroke secondary to distal thromboembolism. Hybrid stents with a micromesh layer have been proposed to address this complication. We developed a micropatterned thin film nitinol (M-TFN) covered stent designed to prevent thromboembolism

  Balloon-Based Local Drug Delivery Revisited. The concept of delivering biologically active compounds into the vessel wall as a single-time dose treatment during an interventional procedure to prevent restenosis has been present for almost 20 years. 17–20 However, despite extensive efforts to improve the efficiency of local arterial delivery through a variety of transfer methods, several Drug delivery systems for stents Drug delivery systems for stents Carter, Andrew; Aggarwal, Meenakshi formidable limitation of percutaneous coronary revascularization. Stent-based drug delivery engenders a number of critical chemical, drug, polymer, and mechanical engineering challenges that must be addressed to develop an effective restenosis ://

Drug-eluting stents (DESs) have been prevailing for the treatment of CAD in the interventional cardiology world owing to their efficacy in significantly reducing restenosis. Current successful DES requires a polymer coating for drug delivery. Clinical trials examining several pharmaceutical agents,?doi=&rep=rep1&type=pdf.   Nitinol Stents. Nitinol is an alloy composed mostly of nickel-titanium as well as cobalt and other metal elements. Nitinol alloy is the material most commonly used in carotid stents nowadays, usually for self-expanding stents. Self-expanding nitinol stents are usually manufactured slightly larger than the size of the target


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Drug delivery coatings for nitinol stents to prevent intimal hyperplasia by Kathryn Davenport Download PDF EPUB FB2

One strategy included the delivery of polymers that produce or release NO, a compound released by ECs to induce vasorelaxation and minimize SMC migration, both of which suppress intimal hyperplasia.

Alternatively, researchers have investigated perivascular delivery of the antiproliferative and anti-inflammatory compounds used in drug A limitation of drug-eluting stents is the inconsistentency of drug delivery; specifically a stent contacts only 15% of the vessel wall and this small area is where drug elution occurs.

21 Using a balloon to deliver drug to the arterial wall allows for uniform delivery with near Metal stents are also commonly used in cardiovascular surgery. While metal forms the basic structure of all stents, this rapidly expanding group of devices includes bare metal nitinol stents composed of nickel and titanium as well as drug-eluting stents (DES) whose metal scaffold is coated with drugs that combat neointimal :// Request PDF | On Aug 1,Shrirang V.

Ranade and others published Drug Delivery Coatings for Coronary Stents | Find, read and cite all the research you need on ResearchGate /_Drug_Delivery_Coatings_for_Coronary_Stents. lamina (EEL), and intimal hyperplasia. Stenting also enlarges the cross-sectional area of the vessel wall.

Stents prevent vessel shrinkage, however intimal hyperplasia can be excessive (adapted from [11]). These macrophages produce additional vascular smooth muscle cell (VSMC) activation elements.

Vascular trauma by angioplasty catheter and stents Stent fracture has been reported as a complication of drug-eluting coronary stenting, in particular sirolimuseluting stents (Lee et al., ). When used in peripheral arteries, drug eluting stents have not shown significant improvements in restenosis rates compared with bare metal stents (Duda et al., ).

@article{osti_, title = {Reduction of Intimal Hyperplasia with Relabeled Stents in a Rabbit Model at 7 and 26 Weeks: An Experimental Study}, author = {Tepe, Gunnar and Dietrich, Tobias and Grafen, Franziska and Brehme, Ute and Muschick, Peter and Dinkelborg, Ludger M and Greschniok, Annette and Claussen, Claus D and Duda, Stephan H}, abstractNote = {The aim of this study was to   Nanoparticle Drug- and Gene-eluting Stents for the Prevention and Treatment of Coronary Restenosis.

polymer-based bioresorbable stents were tested in animals and produced marked inflammation resulting in enhanced intimal hyperplasia and thrombosis Lincoff et al. 78, however, demonstrated in a porcine model that stents composed of poly-L   Nitinol Stents. Nitinol is an alloy composed mostly of nickel-titanium as well as cobalt and other metal elements.

Nitinol alloy is the material most commonly used in carotid stents nowadays, usually for self-expanding stents. Self-expanding nitinol stents are usually manufactured slightly larger than the size of the target :// Initially, the coatings were used to increase the biocompatibility of stents, but later this technique became a platform for the controlled delivery of drug to inhibit intimal hyperplasia.

The coating materials for stents can be broadly classified into four types: inorganic materials,   Bioresorbable stents also enable longer term delivery of drugs to the conduit wall from an internal reservoir and abolish the need for a second surgery to remove the device.

The present review describes recent advances in bioresorbable stents, focus-ing on drug-eluting bioresorbable stents for various applications. Controlled ~meitalz/Articles/ Polyurethane is a very important polymeric biomaterial, widely used in the preparation of implants and medical devices.

This chapter highlights recent research developments in polyurethanes for biomedical applications, including biocompatibility and biostability evaluation, for drug-controlled release carriers, for cardiovascular implants and for medical :// They are biocompatible, and their permeability makes them ideal for drug delivery.

Innumerable studies in animals have used hydrogels to deliver drugs or molecular tools, or both, to prevent intimal hyperplasia, 30 In fact, hydrogels have become a common research tool for the delivery of agents under investigation as inhibitors of restenosis   J Gunn, D Cumberland; Stent coatings and local drug delivery.

State of the art, European Heart Journal, Vol Is 1 DecemberPages –,   Periadventitial delivery systems are ideally suited for small animal research, and may allow the identification of agents that inhibit neointimal proliferation at sites of local delivery after vascular addition, they may be of value in certain clinical situations such as restenosis occurring within the venous limb of A–V shunts in hemodialysis ://   If, for example, delivery is altered in any way, this can be factored into the design of the drug delivery system, i.e.

perhaps a higher dosage of drug is necessary to achieve the same arterial delivery as seen prior to stent implantation. Because the artery may be damaged by implantation of stents, altered delivery of the drug may be of :// Phosphorylcholine-coated metallic stents in rabbit iliac and porcine coronary arteries.

Scand Cardiovasc J. ; 32 (5)– Lincoff AM, Furst JG, Ellis SG, Tuch RJ, Topol EJ. Sustained local delivery of dexamethasone by a novel intravascular eluting stent to prevent restenosis in the porcine coronary injury model.

J Am Coll :// Request PDF | Polymer stent coating for prevention of neointimal hyperplasia | Restenosis has been the principal limitation of bare metal stents. Based upon the presumption that platelet and Drug delivery systems based on drug/polymer coatings on stent struts.

Type D: the metal and heparin to prevent neointimal hyperplasia and throm bo- Stents as a platform for drug ://   Nanoparticle-Mediated Drug Delivery for Restenosis Prevention. For minor atherosclerotic lesions, targeted drug delivery via nanoparticles may be a less invasive option than stents or vascular grafts.

Nanoparticles have been used clinically for targeted drug delivery to cancerous tumors [reviewed in (Brannon-Peppas and Blanchette, )].

For. Drug eluting stents and drug coated balloons are promising technologies and have become an important tool for the endovascular treatment of peripheral artery disease.

The concept of local drug delivery to prevent restenosis due to intimal hyperplasia has been proven in   neointimal hyperplasia and SMC proliferation. Permanent polymer coatings were applied to control the release kinetics of the anti-proliferative drug that acts to minimize neointimal growth.

The sirolimus-eluting stents (SES) used polyethylene-co-vinyl (PEVA) and poly n-butyl methacrylate (PBMA) as a non-erodible polymer releasing%2Fspdf.Nanoparticle Drug- and Gene-eluting Stents for the Prevention and Treatment of Coronary Restenosis. the utilization of the Tsumani TM stent (Terumo Corporation, Tokyo, Japan) as the platform for local simvastatin delivery.

Stent coatings. Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase